A New Nucleoside Analogue with Potent Activity against Mutant sr39 Herpes Simplex Virus-1 (HSV-1) Thymidine Kinase (TK)
نویسندگان
چکیده
منابع مشابه
Suicide Gene Therapy by Herpes Simplex Virus-1 Thymidine Kinase (HSV-TK)
Suicide gene therapy for cancer treatment proposed by Moolten [1] started more than 25 years ago and has gained momentum with little variations in the original technology. At the current statistics, worldwide 1550 clinical trials of gene therapy have been reported (http://www.wiley.co.uk/genmed/clinical) among them 7% using suicide gene therapy. HSV-TK is the most well characterized suicide gen...
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متن کاملAntiviral activity of root extracts from Tagetes minuta against Herpes simplex virus (HSV-1)
A large number of plants have been used by various societies for the treatment of disease. Tagetes minuta L. (Asteraceae) is an annual species native of South American, although it has became widespread throughout the world. It is used in medicinal tea and condiments. Decoction of the plant is used as beverage and as a remedy for common cold, digestive system complaints, stomach upsets, diarrhe...
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متن کاملNon-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase.
5'-O-Trityl derivatives of thymidine (dThd), (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), and their acyclic analogs 1-[(Z)-4-triphenylmethoxy-2-butenyl]thymine (KIN-12) and (E)-5-(2-bromovinyl)-1-[(Z)-4-triphenylmethoxy-2-butenyl]uracil (KIN-52) have been synthesized and evaluated for their inhibitory activity against the amino acid sequence related mitochondrial dThd kinase (TK-2), herpes simp...
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2012
ISSN: 1523-7060,1523-7052
DOI: 10.1021/ol300728a